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Azeez, K. R. A., Saraswati, H., Mosler, T., Hanke, T., Ho-Xuan, H., Neder, N., Sivashanmugam, S. A., Heinz, M., Schwalm, M. P., Giuliani, G., Rathore, R., Kazi, R., Kumar, R., Mitrovic, M., Prieto-Garcia, C., Bailey, H. J., Mathea, S., Hummer, G., Đikić, I., Müller, S., … Knapp, S. (2026). Discovery and Development of a Potent LIMK2 Isoform-Specific Degrader. ACS chemical biology, 21(5), 1158–1176. https://doi.org/10.1021/acschembio.6c00137

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Berner, N., Bayer, F. P., George, A., Kabella, N., Bergamasco, F. L., & Kuster, B. (2026). Proteome-wide dose-response measurements for the characterization of drug mechanism of action. Targetome, 2(1), e001. https://doi.org/10.48130/targetome-0025-0011

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Bhandare, P., Narain, A., Hofstetter, J., Rummel, T., Wenzel, J., Schülein-Völk, C., Lamer, S., Eilers, U., Schlosser, A., Eilers, M., Erhard, F., & Wolf, E. (2024). Phenotypic screens identify SCAF1 as critical activator of RNAPII elongation and global transcription. Nucleic Acids Research, gkae1219. https://doi.org/10.1093/nar/gkae1219

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Cakmak, P., Lun, J. H., Singh, A., Macas, J., Schupp, J., Schuck, J., Mahmoud, Z., Kohler, M., Starzetz, T., Burger, M. C., Steidl, E., Hasse, L. M., Hattingen, E., Plate, K. H., Reiss, Y., & Imkeller, K. (2025). Spatial immune profiling defines a subset of human gliomas with functional tertiary lymphoid structures. Immunity, 58(11), 2847-2863 e2848. https://doi.org/10.1016/j.immuni.2025.09.018

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Dehmer, M., Trunk, K., Gallant, P., Fleischhauer, D., Müller, M., Herold, S., Cossa, G., Conte, F., Koster, J., Sauer, F., Schülein-Völk, C., Ade, C. P., Vidal, R., Kisker, C., Versteeg, R., Beli, P., Vos, S. M., Eilers, M., & Büchel, G. (2025). The USP11/TCEAL1 complex promotes transcription elongation to sustain oncogenic gene expression in neuroblastoma. Genes & Development. https://doi.org/10.1101/gad.352166.124

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Gotthardt, G., Weckesser, J., Tascher, G., Da Gama, S. B., Uckelmann, H. J., Schwalm, M., Mosler, T., Ferrario, G., Münch, C., Knapp, S., & Müller, S. (2024). The cysteine-reactive covalent RNF4 ligand CCW16 induces ferroptosis in AML cells by activation of ROS signaling. bioRxiv. https://doi.org/10.1101/2024.12.12.628083

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Gotthardt, G., Keiten-Schmitz, J., & Müller, S. (2025). Reprogramming SUMO-primed ubiquitylation: opportunities in oncology and neurology. Trends in pharmacological sciences, 46(11), 1117–1129. https://doi.org/10.1016/j.tips.2025.09.002

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Gotthardt, G., Weckesser, J., Tascher, G., Barros da Gama, S., Uckelmann, H. J., Sun, S., Schwalm, M. P., Mosler, T., Ferrario, G., Friedmann Angeli, J. P., Münch, C., Knapp, S., & Müller, S. (2025). Cysteine-reactive covalent chloro-N-acetamide ligands induce ferroptosis mediated cell death. EMBO reports, 26(22), 5501–5532. https://doi.org/10.1038/s44319-025-00593-4

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Haag, A., Němec, V., Janovská, P., Bartošíková, J., Adhikari, B., Müller, J., Schwalm, M. P., Čada, Š., Ohmayer, U., Daub, H., Kim, Y., Born, F., Wolf, E., Bryja, V., & Knapp, S. (2025). Development and Discovery of a Selective Degrader of Casein Kinases 1 δ/ε. Journal of Medicinal Chemistry, 68(1), 506–530. https://doi.org/10.1021/acs.jmedchem.4c02201

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Kabella, N., Bayer, F. P., Stamatiou, K., Abele, M., Sakhteman, A., Chang, Y. C., Wagner, V., Gabriel, A., Krumm, J., Reinecke, M., Holzner, M., Aigner, M., The, M., Hahne, H., Bassermann, F., Ludwig, C., Vagnarelli, P., & Kuster, B. (2025). Proteomic analyses identify targets, pathways, and cellular consequences of oncogenic KRAS signaling. Science signaling, 18(897), eadt6552. https://doi.org/10.1126/scisignal.adt6552

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Klink, N., Urban, S., Seier, J. A., Adhikari, B., Schwalm, M. P., Müller, J., Dorsch, M., Steinbach, P., Jung, J., Vogt, M., Kaschani, F., Koch, J., Führer, S., Kaiser, M., Schulze, N., Knapp, S., Wolf, E., Paschen, A., Grüner, B. M., & Gersch, M. (2026). Targeted degradation of USP7 in solid cancer cells reveals distinct effects of deubiquitinase degraders and inhibitors. Nature communications, 17(1), 4331. https://doi.org/10.1038/s41467-026-72295-x

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Kolak, A., Tschuck, J., Weiß, S. A. I., Kaemena, D., Klimm, K., Galhoz, A., Ringelstetter, L., Fennell, M., Merl-Pham, J., Artati, A., Strasser, S., Garippa, R., Witting, M., Zischka, H., Schick, J. A., Hauck, S. M., Menden, M. P., Vincendeau, M., Stockwell, B. R., & Hadian, K. (2026). MiR-940 Suppresses Ferroptosis by Controlling Expression of Key Regulatory Genes. Advanced science (Weinheim, Baden-Wurttemberg, Germany), e75830. Advance online publication. https://doi.org/10.1002/advs.75830

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Lee, C. Y., Han, S., Haertle, L., Munawar, U., Vogt, C., Streubel, J., Besse, A., Besse, L., Driessen, C., Einsele, H., Waldschmidt, J., Kortüm, M., & Kuster, B. (2026). Proteome profiling reveals NQO2 activity contributing to proteasome inhibitor resistance in multiple myeloma cell lines. Molecular & cellular proteomics : MCP, 101615. Advance online publication. https://doi.org/10.1016/j.mcpro.2026.101615

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Miletić, N., Weckesser, J., Mosler, T., Rathore, R., Hoffmann, M. E., Gehrtz, P., Schlesiger, S., Hartung, I. V., Berner, N., Wilhelm, S., Müller, J., Adhikari, B., Němec, V., Sivashanmugam, S. A., Elson, L., Holzmann, H., Schwalm, M. P., Hoffmann, L., Abdul Azeez, K. R., … Knapp, S. (2025). Workflow for E3 Ligase Ligand Validation for PROTAC Development. ACS Chemical Biology, 20(2), 507–521. https://doi.org/10.1021/acschembio.4c00812

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Müller, J., Daunke, T., Berner, N., Bhandare, P., Gebhardt, A., Hoffmann, L., Diebold, M., Vogt, M., Hofstetter, J., Cruz-Garcia, Y., Dudvarski-Stankovic, N., Schneider, K., Adhikari, B., Lamer, S., Schlosser, A., Büchel, G., Sos, M. L., Küster, B., Knapp, S., Wilhelm, S., … Wolf, E. (2026). AURORA A interacts with DICER and SETD2 to promote S-phase progression. EMBO reports, 10.1038/s44319-026-00850-0. Advance online publication. https://doi.org/10.1038/s44319-026-00850-0

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