CRC/ Transregio 387

Functionalizing the Ubiqitin System against Cancer

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Our Mission

Implications of the ubiquitin system in human cancer biology and therapy

We will generate a holistic discovery hub for the exploitation of functionalized vulnerabilities in the Ub-system (Research Area A) and the application of novel biological insights to either develop compounds directed towards validated Ub-targets or engineer degraders against central oncoproteins that typically evade functional inhibition (Research Area B). In line with our vision of enabling drug development and application to human diseases, both research areas are intrinsically supported by and integrated into three intertwined core projects (Z01-Z03).

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Funding since 2024

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IRTG

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25 Research Projects

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38 Principal Investigators

Project Areas

Our Research Areas

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Project Area A

Mechanism Based Discovery

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Project Area B

Compound based application

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Service Projects and IRTG

Administration and Service

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Publications

Latest publications made in the context of CRC/ TRR 387

Adhikari, B., Schneider, K., Diebold, M., Sotriffer, C., & Wolf, E. (2024). Identification of suitable target/E3 ligase pairs for PROTAC development using a rapamycin-induced proximity assay (RiPA). eLife, 13, RP98450. https://doi.org/10.7554/eLife.98450

Bhandare, P., Narain, A., Hofstetter, J., Rummel, T., Wenzel, J., Schülein-Völk, C., Lamer, S., Eilers, U., Schlosser, A., Eilers, M., Erhard, F., & Wolf, E. (2024). Phenotypic screens identify SCAF1 as critical activator of RNAPII elongation and global transcription. Nucleic Acids Research, gkae1219. https://doi.org/10.1093/nar/gkae1219

Haag, A., Němec, V., Janovská, P., Bartošíková, J., Adhikari, B., Müller, J., Schwalm, M. P., Čada, Š., Ohmayer, U., Daub, H., Kim, Y., Born, F., Wolf, E., Bryja, V., & Knapp, S. (2025). Development and Discovery of a Selective Degrader of Casein Kinases 1 δ/ε. Journal of Medicinal Chemistry, 68(1), 506–530. https://doi.org/10.1021/acs.jmedchem.4c02201

Sflakidou, E., Adhikari, B., Siokatas, C., Wolf, E., & Sarli, V. (2024). Development of 2-Aminoadenine-Based Proteolysis-Targeting Chimeras (PROTACs) as Novel Potent Degraders of Monopolar Spindle 1 and Aurora Kinases. ACS Pharmacology & Translational Science, 7(11), 3488–3501. https://doi.org/10.1021/acsptsci.4c00405

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