A - Mechanism-based Discovery
Project Title: Role of FBXO41 in maintaining the undifferentiated state in acute myeloid leukemia
Project Title: Function and targeting of membrane-bound E3 ligases in AML
Project Title: SLC-regulating E3 ligases as therapeutic targets in AML
Project Title: Role of premature transcription termination in colorectal tumorigenesis
Project Title: Contribution of the ubiquitin proteasome system to ferroptosis resistance in non-small cell lung cancers
Project Title: Targeting the oxidative stress response of non-small cell lung cancers
Project Title: Reprogramming of the E3 ligase/DUB network during oncogenic transformation
Project Title: The role of RNF213 and its variants in lung tumor
Project Title: Discovery and targeting of ubiquitin-dependent synthetic vulnerabilities in NSCLC
Project Title: Structural mechanisms underlying MYC ubiquitylation
Project Title: Cross-species screens and investigation of UPS vulnerabilities in high grade lymphoma
Project Title: Understanding and breaking proteasome inhibitor resistance in multiple myeloma patients
Project Title: Deciphering vulnerabilities in the USP1/Fanconi anemia axis as anticancer target in AML