Projects
Area A
Area B
Area Z
A - Mechanism-based Discovery

A01

Project Title:

Role of FBXO41 in maintaining the undifferentiated state in acute myeloid leukemia

A02

Project Title:

Function and targeting of membrane-bound E3 ligases in AML

A03

Project Title:

SLC-regulating E3 ligases as therapeutic targets in AML

A04

Project Title:

Role of premature transcription termination in colorectal tumorigenesis

A05

Project Title:

Contribution of the ubiquitin proteasome system to ferroptosis resistance in non-small cell lung cancers

A06

Project Title:

Targeting the oxidative stress response of non-small cell lung cancers

A07

Project Title:

Reprogramming of the E3 ligase/DUB network during oncogenic transformation

A08

Project Title:

The role of RNF213 and its variants in lung tumor

A09

Project Title:

Discovery and targeting of ubiquitin-dependent synthetic vulnerabilities in NSCLC

A10

Project Title:

Structural mechanisms underlying MYC ubiquitylation

A11

Project Title:

Cross-species screens and investigation of UPS vulnerabilities in high grade lymphoma

A12

Project Title:

Understanding and breaking proteasome inhibitor resistance in multiple myeloma patients

A13

Project Title:

Deciphering vulnerabilities in the USP1/Fanconi anemia axis as anticancer target in AML

B - Compound-based Application

B01

Project Title:

Harnessing novel E3 ligases for cancer-specific degradation of oncogenic targets by PROTACs

B02

Project Title:

Targeting E3 ligase functions in AML

B03

Project Title:

Organogold compounds as “smart” residue specific chemical modifiers: towards new generation Gold-PROTACs

B04

Project Title:

Understanding ubiquitylation and FATylation by UBA6 in lung cancer

B05

Project Title:

Targeting OTUD6B in multiple myeloma

B06

Project Title:

Design of potent and selective USP25 and USP28 inhibitors

B07

Project Title:

Analyzing and targeting non-catalytic functions of Aurora-A in AML

B08

Project Title:

Targeted proteasomal degradation of m6A-reader proteins in colorectal carcinoma

Z - Service Projects

Z01

Project Title:

Target and Compound Profiling

Z02

Project Title:

Drug/Probe Discovery Platform

Z03

Project Title:

Functional Human and Mouse Pathology

Z04

Project Title:

Central Tasks of the Collaborative Research Center