Z01
Target and Compound Profiling
Project Summary
The ubiquitin-proteasome system (UPS) field faces significant challenges, including identifying actionable biological vulnerabilities and developing chemical modulators for UPS-related enzymes. This project, “Z01 – Target and Compound Profiling,” aims to advance these areas by supporting scientists in understanding the biology of oncogenic target proteins and their chemical modulation. Key objectives include studying cellular dependencies, phenotypic responses to target perturbations, and profiling compound interactions and selectivity. This project provides access to cutting-edge technologies, such as high-content microscopy, live-cell imaging, and chemical proteomics, which are not commonly available in cell biology labs. Additionally, tailored experimental design, bioinformatic analyses, and collaborative knowledge sharing with related projects (Z02/Z03) ensure a seamless pipeline for compound discovery. The ultimate goal is to identify new cancer therapy targets, discover promising molecular leads, and support technological advancements that align with the field’s rapid progress. Collaboration with 14 CRC research projects underscores the commitment to transformative research in UPS biology and therapeutic development.
