B07

Analyzing and targeting non-catalytic functions of Aurora-A in AML

Project Summary

Several kinase inhibitors of Aurora-A have been developed as anticancer agents. Unfortunately, none of them has been clinically successful due to off-target activity against Aurora-B and non-catalytic functions of Aurora-A that cannot be blocked by kinase inhibitors. The central hypothesis of this project is that PROTACs may be able to overcome these limitations by targeting not only the catalytic function of Aurora-A, but also important non-catalytic oncogenic functions. We will test this hypothesis in cellular and murine models of AML, as we have observed that AML cells are particularly sensitive to Aurora-A degradation.

Researchers