B01

Harnessing novel E3 ligases for cancer-specific degradation of oncogenic targets by PROTACs

Project Summary

In project B01, Elmar Wolf and Hermann Schindelin address the topic of PROTAC development that to date harnesses E3 ligases which are commonly expressed in healthy tissues and are not essential for tumor cells, thus rendering them not well suited as tumor therapeutics. This project thus aims to identify E3 ligases that show less common expression in healthy tissues and are essential for the focus entities of this CRC/TRR. This approach will enable the development of a new generation of anti-cancer PROTACs, which provoke less therapy-induced toxicity and resistance.

Researchers